History of a Pioneering Neuropeptide: Substance P
نویسنده
چکیده
1 Extraction, Biological Testing and Structural Elucidation . . . . . . . . . . . . 1 2 Masanori Otsuka and the Action of Substance P in the Spinal Cord . . . . . . 8 3 Radioimmunoassay and Immunohistochemistry of Substance P . . . . . . . . 8 4 Nicolas Jancs and Capsaicin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 5 Peptide and Nonpeptide Transmitters in Primary Afferent Neurons . . . . . . 12 6 Involvement of Substance P in Autonomic and Neuroendocrine Reflexes . . . 13 7 Tachykinin Genes, Precursors and Receptors . . . . . . . . . . . . . . . . . . . 15 8 Colocalization of Substance P with Peptides and Amino Acids . . . . . . . . . 15 9 Substance P and Neurokinin A in the Gut. . . . . . . . . . . . . . . . . . . . . 17 10 Tachykinin Receptor Antagonists: The Role of Substance P Revisited . . . . . 18 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
منابع مشابه
Reviewing the Association between the History of Parental Substance Abuse and the Rate of Child Abuse
Background: Substance abuse is a social, and health problem in Middle Eastern countries such as Iran. One of its most devastating effects is domestic violence against children. This study examined the association between the history of parental substance abuse, and rate of child abuse in Ahvaz, Iran. Methods: This was a case-control study. The study population included all parents with high sch...
متن کاملImmunohistochemical study of the endocrine cells in the stomach and pyloric caeca of the mountain trout, Salmo trutta macrostigma
The endocrine cells of Salmo trutta macrostigma stomach and pyloric caeca have been investigated using immunohistochemical techniques. 8 antisera were tested and 6 of them were detected in the endocrine cells serotonin, somatostatin, substance P, galanin, CCK and neuropeptide Y. These immunoreactive cells are described for the first time in the stomach and pyloric caeaca of Salmo trut...
متن کاملSubstance P as a potential biomarker of pain assessment in dogs
Background: Substance P (SP) is a neuropeptide that functions as a neuromodulator. It is released mainly in the brain stem and in nerve endings. Aims: The present study aimed to provide fundamental data that may be applied to the assessment of pain in dogs by evaluating their serum SP concentrations. Methods: Two groups of dogs were designated ...
متن کاملImmunohistochemical study of the endocrine cells in the stomach and pyloric caeca of the mountain trout, Salmo trutta macrostigma
The endocrine cells of Salmo trutta macrostigma stomach and pyloric caeca have been investigated using immunohistochemical techniques. 8 antisera were tested and 6 of them were detected in the endocrine cells serotonin, somatostatin, substance P, galanin, CCK and neuropeptide Y. These immunoreactive cells are described for the first time in the stomach and pyloric caeaca of Salmo trutta macros...
متن کاملImmunohistochemical Evidence for the Presence of a Vasoactive Intestinal Peptide, Neuropeptide Y, and Substance P, in Rat Adrenal Cortex after Acute Heat Stress
Immunohistochemistry revealed the presence of Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), and the absence of Substance P (SP) immunoreactivity in the rat adrenal cortex. VIPand NPY-immunoreactivity were detected in nerve fibers around the small blood vessels projecting into the capsule and cortical zones surrounding blood vessels and cortical cells. After acute heat stress, VIPan...
متن کامل